According to the WHO (World Health Organization), early diagnosis of diseases is one of the key factors in the world to save lives and reduce the cost of treatment. Faced with these recommendations, in vitrodiagnostic tests can prevent, detect, diagnose, evolve, monitor and manage a pathology, but also select and follow a therapy. Current in vitro tests are designed biological products coupled with fluorescent molecules to detect biomarkers responsible for diseases. These dyes emit a signal that can be observed and quantified and represent one of the central elements to diagnose a pathology.
Today, the detection of biomarkers is addressed by several products already marketed whose performance is moderate. Specifically, developed in the 2000s, fluorescent markers currently used don’t answer the needs of the market for a much more sensitive detection, accurate, fast and cheaper.
Our solution: NanoBright technology is HK-Dtech’s solution to improve the sensitivity of detection of biomarkers. It consists to develop high performance fluorescent nano-molecules with unique characteristics. Thanks to their properties, to their high efficiency and to their simplicity of use, this new technology will allow to replace the fluorescent molecules on the market. The summary of unique features of NanoBright is shown in the following figure:
Our technology stands out thanks to its fluorescent properties eliminating the defects of current technologies. Among the products on the markets, 3 categories of fluorescent molecules stand out by the habit of use of the customer. A comparison between these 3 families of molecules and NanoBright, the technology of HK-Dtech is presented in the table below:
This comparative table differentiates the advantages and the disadvantages of each technology according to the essential properties for the user. For example, brightness is an essential parameter of comparison. Strong brightness implies more precise detection and reduce detection limits. As a result, this new technology allows to use new unexploited biomarkers for the detection of pathologies, to detect of an earlier disease or to improve measuring devices. Another point related to brightness is the reduction of biological materials that induces cost reduction for detection kits. In addition, the combination with the specificity and the lifetime increases the properties mentioned above compared to the products currently used. The modulation and the control of the surface of the nanoparticle is a parameter not mentioned in the table but allows to NanoBright to distinguish itself from other technologies and brings a significant added value because it is important to know the number of biological entities that are added around the nanometric particle.